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Enhanced spreading and adhesion mediated by outside-in signaling in KI platelets. Platelet adhesion was monitored by in-cell Western blot of β

Integrins are transmembrane proteins that connect with the ECM to link the extracellular setting towards the intracellular cytoskeleton.

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Engagement of integrins because of the extracellular matrix initiates signaling cascades that push various mobile functions, like neuronal migration and axonal pathfinding from the Mind. Multiple traces of evidence link the ITGB3

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locus, changing the endogenous Ser32Gln33. Pro32Pro33 mice have altered adhesion and enhanced velocity in aggregation, leading to a proaggregatory phenotype observed in tail bleeding and nonfatal thromboembolism.

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